Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 (H3Ub2) by UHRF1 as an essential mechanism to recruit DNMT1 to chromatin. Here, we show that PCNA-associated fact...

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書誌詳細
出版年:Nat Commun
主要な著者: Nishiyama, Atsuya, Mulholland, Christopher B., Bultmann, Sebastian, Kori, Satomi, Endo, Akinori, Saeki, Yasushi, Qin, Weihua, Trummer, Carina, Chiba, Yoshie, Yokoyama, Haruka, Kumamoto, Soichiro, Kawakami, Toru, Hojo, Hironobu, Nagae, Genta, Aburatani, Hiroyuki, Tanaka, Keiji, Arita, Kyohei, Leonhardt, Heinrich, Nakanishi, Makoto
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060239/
https://ncbi.nlm.nih.gov/pubmed/32144273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15006-4
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