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Polypyrimidine tract-binding proteins are essential for B cell development
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of bot...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7058386/ https://ncbi.nlm.nih.gov/pubmed/32081131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53557 |
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