Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation

Polypyrimidine tract binding protein (PTB) is a major hnRNP protein with multiple roles in mRNA metabolism, including regulation of alternative splicing and internal ribosome entry site-driven translation. We show here that a fourfold overexpression of PTB results in a 75% reduction of mRNA levels p...

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Autores principales: Castelo-Branco, Pedro, Furger, Andre, Wollerton, Matthew, Smith, Christopher, Moreira, Alexandra, Proudfoot, Nick
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Gene Expression
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC400487/
https://ncbi.nlm.nih.gov/pubmed/15121839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.10.4174-4183.2004
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