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Polypyrimidine Tract Binding Protein Modulates Efficiency of Polyadenylation

Polypyrimidine tract binding protein (PTB) is a major hnRNP protein with multiple roles in mRNA metabolism, including regulation of alternative splicing and internal ribosome entry site-driven translation. We show here that a fourfold overexpression of PTB results in a 75% reduction of mRNA levels p...

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Pubblicato in:Mol Cell Biol
Autori principali: Castelo-Branco, Pedro, Furger, Andre, Wollerton, Matthew, Smith, Christopher, Moreira, Alexandra, Proudfoot, Nick
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2004
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400487/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15121839/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.24.10.4174-4183.2004
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