Polypyrimidine tract-binding proteins are essential for B cell development

Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development. We show that PTBP2 compensates for PTBP1 in B cell ontogeny as deletion of bot...

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Bibliographic Details
Published in:eLife
Main Authors: Monzón-Casanova, Elisa, Matheson, Louise S, Tabbada, Kristina, Zarnack, Kathi, Smith, Christopher WJ, Turner, Martin
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2020
Subjects:
Chromosomes and Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7058386/
https://ncbi.nlm.nih.gov/pubmed/32081131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53557
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