B cell–derived IL35 drives STAT3-dependent CD8(+) T-cell exclusion in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by paucity of tumor-proximal CD8(+) T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8(+) T-cell exclusion and resistance to immunotherapy are not well known. Here, u...

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Vydáno v:Cancer Immunol Res
Hlavní autoři: Mirlekar, Bhalchandra, Michaud, Daniel, Lee, Samuel J., Kren, Nancy P., Harris, Cameron, Greene, Kevin, Goldman, Emily C., Gupta, Gaorav P., Fields, Ryan C., Hawkins, William G., DeNardo, David G., Rashid, Naim U., Yeh, Jen Jen, McRee, Autumn J., Vincent, Benjamin G., Vignali, Dario A.A., Pylayeva-Gupta, Yuliya
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056532/
https://ncbi.nlm.nih.gov/pubmed/32024640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0349
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