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IL35 hinders endogenous antitumor T-cell immunity and responsiveness to immunotherapy in pancreatic cancer

Although successes in cancer immunotherapy have generated considerable excitement, this form of treatment has been largely ineffective in patients with pancreatic ductal adenocarcinoma (PDA). Mechanisms that contribute to the poor antitumor immune response in PDA are not well understood. Here, we de...

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Bibliographic Details
Published in:Cancer Immunol Res
Main Authors: Mirlekar, Bhalchandra, Michaud, Daniel, Searcy, Ryan, Greene, Kevin, Pylayeva-Gupta, Yuliya
Format: Artigo
Language:Inglês
Published: 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6125203/
https://ncbi.nlm.nih.gov/pubmed/29980536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0710
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