B cell–derived IL35 drives STAT3-dependent CD8(+) T-cell exclusion in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by paucity of tumor-proximal CD8(+) T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8(+) T-cell exclusion and resistance to immunotherapy are not well known. Here, u...

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Gepubliceerd in:Cancer Immunol Res
Hoofdauteurs: Mirlekar, Bhalchandra, Michaud, Daniel, Lee, Samuel J., Kren, Nancy P., Harris, Cameron, Greene, Kevin, Goldman, Emily C., Gupta, Gaorav P., Fields, Ryan C., Hawkins, William G., DeNardo, David G., Rashid, Naim U., Yeh, Jen Jen, McRee, Autumn J., Vincent, Benjamin G., Vignali, Dario A.A., Pylayeva-Gupta, Yuliya
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056532/
https://ncbi.nlm.nih.gov/pubmed/32024640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0349
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