B cell–derived IL35 drives STAT3-dependent CD8(+) T-cell exclusion in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by paucity of tumor-proximal CD8(+) T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8(+) T-cell exclusion and resistance to immunotherapy are not well known. Here, u...

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Publicado no:Cancer Immunol Res
Main Authors: Mirlekar, Bhalchandra, Michaud, Daniel, Lee, Samuel J., Kren, Nancy P., Harris, Cameron, Greene, Kevin, Goldman, Emily C., Gupta, Gaorav P., Fields, Ryan C., Hawkins, William G., DeNardo, David G., Rashid, Naim U., Yeh, Jen Jen, McRee, Autumn J., Vincent, Benjamin G., Vignali, Dario A.A., Pylayeva-Gupta, Yuliya
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056532/
https://ncbi.nlm.nih.gov/pubmed/32024640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0349
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