B cell–derived IL35 drives STAT3-dependent CD8(+) T-cell exclusion in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignancy characterized by paucity of tumor-proximal CD8(+) T cells and resistance to immunotherapeutic interventions. Cancer-associated mechanisms that elicit CD8(+) T-cell exclusion and resistance to immunotherapy are not well known. Here, u...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Immunol Res
Prif Awduron: Mirlekar, Bhalchandra, Michaud, Daniel, Lee, Samuel J., Kren, Nancy P., Harris, Cameron, Greene, Kevin, Goldman, Emily C., Gupta, Gaorav P., Fields, Ryan C., Hawkins, William G., DeNardo, David G., Rashid, Naim U., Yeh, Jen Jen, McRee, Autumn J., Vincent, Benjamin G., Vignali, Dario A.A., Pylayeva-Gupta, Yuliya
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7056532/
https://ncbi.nlm.nih.gov/pubmed/32024640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0349
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