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The Effect of CpG Sequences on Capsid-Specific CD8(+) T Cell Responses to AAV Vector Gene Transfer
Transfer of genes by adeno-associated virus (AAV) vectors is benefiting patients with particular genetic defects. Challenges remain by rejection of AAV-transduced cells, which may be caused by CD8(+) T lymphocytes directed to AAV capsid antigens. Reducing the number of CpG motifs from the genome of...
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| Pubblicato in: | Mol Ther |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Gene & Cell Therapy
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7054717/ https://ncbi.nlm.nih.gov/pubmed/31839483 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.014 |
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