Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris (Komagataella phaffii): Impact on Cell Physiology and Recombinant Production of Secreted Proteins

High-level expression and secretion of heterologous proteins in yeast cause an increased energy demand, which may result in altered metabolic flux distributions. Moreover, recombinant protein overproduction often results in endoplasmic reticulum (ER) stress and oxidative stress, causing deviations f...

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Dettagli Bibliografici
Pubblicato in:Appl Environ Microbiol
Autori principali: Tomàs-Gamisans, Màrius, Andrade, Cristiane Conte Paim, Maresca, Francisco, Monforte, Sergi, Ferrer, Pau, Albiol, Joan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2020
Soggetti:
Biotechnology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054088/
https://ncbi.nlm.nih.gov/pubmed/31757828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02038-19
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