Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris (Komagataella phaffii): Impact on Cell Physiology and Recombinant Production of Secreted Proteins

High-level expression and secretion of heterologous proteins in yeast cause an increased energy demand, which may result in altered metabolic flux distributions. Moreover, recombinant protein overproduction often results in endoplasmic reticulum (ER) stress and oxidative stress, causing deviations f...

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發表在:Appl Environ Microbiol
Main Authors: Tomàs-Gamisans, Màrius, Andrade, Cristiane Conte Paim, Maresca, Francisco, Monforte, Sergi, Ferrer, Pau, Albiol, Joan
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2020
主題:
Biotechnology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054088/
https://ncbi.nlm.nih.gov/pubmed/31757828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02038-19
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