Redox Engineering by Ectopic Overexpression of NADH Kinase in Recombinant Pichia pastoris (Komagataella phaffii): Impact on Cell Physiology and Recombinant Production of Secreted Proteins

High-level expression and secretion of heterologous proteins in yeast cause an increased energy demand, which may result in altered metabolic flux distributions. Moreover, recombinant protein overproduction often results in endoplasmic reticulum (ER) stress and oxidative stress, causing deviations f...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Appl Environ Microbiol
Egile Nagusiak: Tomàs-Gamisans, Màrius, Andrade, Cristiane Conte Paim, Maresca, Francisco, Monforte, Sergi, Ferrer, Pau, Albiol, Joan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2020
Gaiak:
Biotechnology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054088/
https://ncbi.nlm.nih.gov/pubmed/31757828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02038-19
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