Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities

Previously, we designed and synthesized a series of bis-substituted aromatic amide-based histone deacetylase (HDAC) inhibitors. In this study, we report the replacement of a bromine atom by different amides on the phenyl ring of the CAP region. Representative compounds 9d and 10k exhibited low nanom...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Ge, Di, Han, Lina, Yang, Feifei, Zhao, Na, Yang, Yang, Zhang, Hua, Chen, Yihua
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053699/
https://ncbi.nlm.nih.gov/pubmed/32180916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00306a
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