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Development of hydroxamate-based histone deacetylase inhibitors of bis-substituted aromatic amides with antitumor activities
Previously, we designed and synthesized a series of bis-substituted aromatic amide-based histone deacetylase (HDAC) inhibitors. In this study, we report the replacement of a bromine atom by different amides on the phenyl ring of the CAP region. Representative compounds 9d and 10k exhibited low nanom...
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| izdano v: | Medchemcomm |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Royal Society of Chemistry
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7053699/ https://ncbi.nlm.nih.gov/pubmed/32180916 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00306a |
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