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Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC(50) values, with the best compound (10e) being nearly 90 times more active than vorinostat (SAHA) against...
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| Publicado en: | Molecules |
|---|---|
| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6680717/ https://ncbi.nlm.nih.gov/pubmed/31311163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24142569 |
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