Loading...
Design, Synthesis and Biological Evaluation of Novel Coumarin-Based Hydroxamate Derivatives as Histone Deacetylase (Hdac) Inhibitors with Antitumor Activities
A series of novel coumarin-based hydroxamate derivatives were designed and synthesized as histone deacetylase inhibitors (HDACis). Selective compounds showed a potent HDAC inhibition with nM IC(50) values, with the best compound (10e) being nearly 90 times more active than vorinostat (SAHA) against...
Na minha lista:
| Udgivet i: | Molecules |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2019
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6680717/ https://ncbi.nlm.nih.gov/pubmed/31311163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules24142569 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|