MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR). The biology of endogenous MANF in the mammalian brain is unknown and therefore we studied the brain phenotype of MANF-defic...

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Pubblicato in:eNeuro
Autori principali: Pakarinen, Emmi, Danilova, Tatiana, Võikar, Vootele, Chmielarz, Piotr, Piepponen, Petteri, Airavaara, Mikko, Saarma, Mart, Lindahl, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2020
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Research Article: New Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053174/
https://ncbi.nlm.nih.gov/pubmed/32005751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0477-19.2019
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