MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR). The biology of endogenous MANF in the mammalian brain is unknown and therefore we studied the brain phenotype of MANF-defic...

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Publicado no:eNeuro
Main Authors: Pakarinen, Emmi, Danilova, Tatiana, Võikar, Vootele, Chmielarz, Piotr, Piepponen, Petteri, Airavaara, Mikko, Saarma, Mart, Lindahl, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Article: New Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053174/
https://ncbi.nlm.nih.gov/pubmed/32005751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0477-19.2019
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