MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) localized protein that regulates ER homeostasis and unfolded protein response (UPR). The biology of endogenous MANF in the mammalian brain is unknown and therefore we studied the brain phenotype of MANF-defic...

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Publicat a:eNeuro
Autors principals: Pakarinen, Emmi, Danilova, Tatiana, Võikar, Vootele, Chmielarz, Piotr, Piepponen, Petteri, Airavaara, Mikko, Saarma, Mart, Lindahl, Maria
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2020
Matèries:
Research Article: New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7053174/
https://ncbi.nlm.nih.gov/pubmed/32005751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0477-19.2019
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