A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals

Neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease, and their levels correlate with the severity of cognitive dysfunction in humans. However, experimental evidence suggests that soluble tau species cause cognitive deficits and memory impairment. Our recent study suggests that...

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Publicat a:Sci Rep
Autors principals: Liu, Peng, Smith, Benjamin R., Montonye, Michelle L., Kemper, Lisa J., Leinonen-Wright, Kailee, Nelson, Kathryn M., Higgins, LeeAnn, Guerrero, Candace R., Markowski, Todd W., Zhao, Xiaohui, Petersen, Ashley J., Knopman, David S., Petersen, Ronald C., Ashe, Karen H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052165/
https://ncbi.nlm.nih.gov/pubmed/32123248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60777-x
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