Developmental Pathogenicity of 4-Repeat Human Tau Is Lost with the P301L Mutation in Genetically Matched Tau-Transgenic Mice

Tau is a microtubule-associated protein that becomes dysregulated in a group of neurodegenerative diseases called tauopathies. Differential tau isoforms, expression levels, promoters, and disruption of endogenous genes in transgenic mouse models of tauopathy make it difficult to draw definitive conc...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Gamache, Julia E., Kemper, Lisa, Steuer, Elizabeth, Leinonen-Wright, Kailee, Choquette, Jessica M., Hlynialuk, Chris, Benzow, Kellie, Vossel, Keith A., Xia, Weiming, Koob, Michael D., Ashe, Karen H.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6939485/
https://ncbi.nlm.nih.gov/pubmed/31685653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1256-19.2019
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