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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice.

Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulation of autophagy. Here, we studied the effect of t...

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Автори: Sefika Ozcelik, Graham Fraser, Perrine Castets, Véronique Schaeffer, Zhiva Skachokova, Karin Breu, Florence Clavaguera, Michael Sinnreich, Ludwig Kappos, Michel Goedert, Markus Tolnay, David Theo Winkler
Формат: Artigo
Мова:Inglês
Опубліковано: Public Library of Science (PLoS) 2013-01-01
Серія:PLoS ONE
Онлайн доступ:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0062459&type=printable
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