Nucleolar localization of RAG1 modulates V(D)J recombination activity

V(D)J recombination assembles and diversifies Ig and T cell receptor genes in developing B and T lymphocytes. The reaction is initiated by the RAG1-RAG2 protein complex which binds and cleaves at discrete gene segments in the antigen receptor loci. To identify mechanisms that regulate V(D)J recombin...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Brecht, Ryan M., Liu, Catherine C., Beilinson, Helen A., Khitun, Alexandra, Slavoff, Sarah A., Schatz, David G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049140/
https://ncbi.nlm.nih.gov/pubmed/32047031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1920021117
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