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Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution
Human cytochrome P450 3A4 (CYP3A4) is a membrane-associated monooxygenase that is responsible for metabolizing >50% of the pharmaceuticals in the current market, so studying its chemical mechanism and structural changes upon ligand binding will help provide deeper insights into drug metabolism an...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7048403/ https://ncbi.nlm.nih.gov/pubmed/31456404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00620 |
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