Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution

Human cytochrome P450 3A4 (CYP3A4) is a membrane-associated monooxygenase that is responsible for metabolizing >50% of the pharmaceuticals in the current market, so studying its chemical mechanism and structural changes upon ligand binding will help provide deeper insights into drug metabolism an...

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Bibliographic Details
Published in:Biochemistry
Main Authors: Chuo, Shih-Wei, Liou, Shu-Hao, Wang, Lee-Ping, Britt, R. David, Poulos, Thomas L., Sevrioukova, Irina F., Goodin, David B.
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048403/
https://ncbi.nlm.nih.gov/pubmed/31456404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00620
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