The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the unfolded protein response (UPR) kinase, protein kina...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Ther Oncolytics
Main Authors: McLaughlin, Martin, Pedersen, Malin, Roulstone, Victoria, Bergerhoff, Katharina F., Smith, Henry G., Whittock, Harriet, Kyula, Joan N., Dillon, Magnus T., Pandha, Hardev S., Vile, Richard, Melcher, Alan A., Harrington, Kevin J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047134/
https://ncbi.nlm.nih.gov/pubmed/32128359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.01.001
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados