When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes a state of cellular stress known as ER stress. The cells respond to ER stress by activating the unfolded protein response (UPR), a signaling network emerging from the ER-anchored receptors IRE1α, PERK and ATF6. The UPR aims a...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Rojas-Rivera, Diego, Delvaeye, Tinneke, Roelandt, Ria, Nerinckx, Wim, Augustyns, Koen, Vandenabeele, Peter, Bertrand, Mathieu J M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5442476/
https://ncbi.nlm.nih.gov/pubmed/28452996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2017.58
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