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RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are under evaluation in clinical trials (a.o. AT9283, AZD1152, Da...
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| Publicado no: | Cell Death Dis |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5833749/ https://ncbi.nlm.nih.gov/pubmed/29434255 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0245-7 |
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