RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)

The Aurora kinase family (Aurora A, B and C) are crucial regulators of several mitotic events, including cytokinesis. Increased expression of these kinases is associated with tumorigenesis and several compounds targeting Aurora kinase are under evaluation in clinical trials (a.o. AT9283, AZD1152, Da...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Martens, Sofie, Goossens, Vera, Devisscher, Lars, Hofmans, Sam, Claeys, Polien, Vuylsteke, Marnik, Takahashi, Nozomi, Augustyns, Koen, Vandenabeele, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833749/
https://ncbi.nlm.nih.gov/pubmed/29434255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0245-7
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