The PERK Inhibitor GSK2606414 Enhances Reovirus Infection in Head and Neck Squamous Cell Carcinoma via an ATF4-Dependent Mechanism

Reovirus type 3 Dearing (reovirus) is a tumor-selective oncolytic virus currently under evaluation in clinical trials. Here, we report that the therapeutic efficacy of reovirus in head and neck squamous cell cancer can be enhanced by targeting the unfolded protein response (UPR) kinase, protein kina...

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Gepubliceerd in:Mol Ther Oncolytics
Hoofdauteurs: McLaughlin, Martin, Pedersen, Malin, Roulstone, Victoria, Bergerhoff, Katharina F., Smith, Henry G., Whittock, Harriet, Kyula, Joan N., Dillon, Magnus T., Pandha, Hardev S., Vile, Richard, Melcher, Alan A., Harrington, Kevin J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047134/
https://ncbi.nlm.nih.gov/pubmed/32128359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.01.001
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