The protein C activator AB002 rapidly interrupts thrombus development in baboons

Although thrombin is a key enzyme in the coagulation cascade and is required for both normal hemostasis and pathologic thrombogenesis, it also participates in its own negative feedback via activation of protein C, which downregulates thrombin generation by enzymatically inactivating factors Va and V...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Tucker, Erik I., Verbout, Norah G., Markway, Brandon D., Wallisch, Michael, Lorentz, Christina U., Hinds, Monica T., Shatzel, Joseph J., Pelc, Leslie A., Wood, David C., McCarty, Owen J. T., Di Cera, Enrico, Gruber, András
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046603/
https://ncbi.nlm.nih.gov/pubmed/31977000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019002771
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