Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Butts, Brittany, Ahmed, Mustafa I., Bajaj, Navkaranbir S., Cox Powell, Pamela, Pat, Betty, Litovsky, Silvio, Gupta, Himanshu, Lloyd, Steven G., Denney, Thomas S., Zhang, Xiaoxia, Aban, Inmaculada, Sadayappan, Sakthivel, McNamara, James W., Watson, Michael J., Ferrario, Carlos M., Collawn, James F., Lewis, Clifton, Davies, James E., Dell’Italia, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046515/
https://ncbi.nlm.nih.gov/pubmed/32140620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.11.006
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