Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...

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Dades bibliogràfiques
Publicat a:JACC Basic Transl Sci
Autors principals: Butts, Brittany, Ahmed, Mustafa I., Bajaj, Navkaranbir S., Cox Powell, Pamela, Pat, Betty, Litovsky, Silvio, Gupta, Himanshu, Lloyd, Steven G., Denney, Thomas S., Zhang, Xiaoxia, Aban, Inmaculada, Sadayappan, Sakthivel, McNamara, James W., Watson, Michael J., Ferrario, Carlos M., Collawn, James F., Lewis, Clifton, Davies, James E., Dell’Italia, Louis J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
CLINICAL RESEARCH
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046515/
https://ncbi.nlm.nih.gov/pubmed/32140620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.11.006
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