Reduced Left Atrial Emptying Fraction and Chymase Activation in Pathophysiology of Primary Mitral Regurgitation

Increasing left atrial (LA) size predicts outcomes in patients with isolated mitral regurgitation (MR). Chymase is plentiful in the human heart and affects extracellular matrix remodeling. Chymase activation correlates to LA fibrosis, LA enlargement, and a decreased total LA emptying fraction in add...

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Vydáno v:JACC Basic Transl Sci
Hlavní autoři: Butts, Brittany, Ahmed, Mustafa I., Bajaj, Navkaranbir S., Cox Powell, Pamela, Pat, Betty, Litovsky, Silvio, Gupta, Himanshu, Lloyd, Steven G., Denney, Thomas S., Zhang, Xiaoxia, Aban, Inmaculada, Sadayappan, Sakthivel, McNamara, James W., Watson, Michael J., Ferrario, Carlos M., Collawn, James F., Lewis, Clifton, Davies, James E., Dell’Italia, Louis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2020
Témata:
CLINICAL RESEARCH
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046515/
https://ncbi.nlm.nih.gov/pubmed/32140620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2019.11.006
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