Primacy of cardiac chymase over angiotensin converting enzyme as an angiotensin-(1-12) metabolizing enzyme

We showed previously that rat angiotensin-(1-12) [Ang-(1-12)] is metabolized by chymase and angiotensin converting enzyme (ACE) to generate Angiotensin II (Ang II). Here, we investigated the affinity of cardiac chymase and ACE enzymes for Ang-(1-12) and Angiotensin I (Ang I) substrates. Native plasm...

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Bibliografiset tiedot
Julkaisussa:Biochem Biophys Res Commun
Päätekijät: Ahmad, Sarfaraz, Varagic, Jasmina, VonCannon, Jessica L., Groban, Leanne, Collawn, James F., Dell'Italia, Louis J., Ferrario, Carlos M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2016
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207032/
https://ncbi.nlm.nih.gov/pubmed/27465904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2016.07.100
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