Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division

Polo-like kinases (Plks) are key cell cycle regulators. They contain a kinase domain followed by a polo-box domain that recognizes phosphorylated substrates and enhances their phosphorylation. The regulatory subunit of the Dbf4-dependent kinase complex interacts with the polo-box domain of Cdc5 (the...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Almawi, Ahmad W., Langlois-Lemay, Laurence, Boulton, Stephen, Rodríguez González, Javier, Melacini, Giuseppe, D’Amours, Damien, Guarné, Alba
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042354/
https://ncbi.nlm.nih.gov/pubmed/32099015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60344-4
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