The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

Centrioles are key microtubule polarity determinants. Centriole duplication is tightly controlled to prevent cells from developing multipolar spindles, a situation that promotes chromosomal instability. A conserved component in the duplication pathway is Plk4, a polo kinase family member that locali...

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Bibliographic Details
Main Authors: Slevin, Lauren K., Nye, Jonathan, Pinkerton, Derek C., Buster, Daniel W., Rogers, Gregory C., Slep, Kevin C.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496063/
https://ncbi.nlm.nih.gov/pubmed/23000383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.025
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