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The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

Centrioles are key microtubule polarity determinants. Centriole duplication is tightly controlled to prevent cells from developing multipolar spindles, a situation that promotes chromosomal instability. A conserved component in the duplication pathway is Plk4, a polo kinase family member that locali...

詳細記述

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書誌詳細
主要な著者: Slevin, Lauren K., Nye, Jonathan, Pinkerton, Derek C., Buster, Daniel W., Rogers, Gregory C., Slep, Kevin C.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496063/
https://ncbi.nlm.nih.gov/pubmed/23000383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.025
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