The Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole Duplication

Centrioles are key microtubule polarity determinants. Centriole duplication is tightly controlled to prevent cells from developing multipolar spindles, a situation that promotes chromosomal instability. A conserved component in the duplication pathway is Plk4, a polo kinase family member that locali...

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Bibliografiske detaljer
Main Authors: Slevin, Lauren K., Nye, Jonathan, Pinkerton, Derek C., Buster, Daniel W., Rogers, Gregory C., Slep, Kevin C.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496063/
https://ncbi.nlm.nih.gov/pubmed/23000383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.08.025
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