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Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability

Polo-like kinases (PLKs) are evolutionarily conserved kinases essential for cell cycle regulation. These kinases are characterized by the presence of a C-terminal phosphopeptide-interaction domain, the polo-box domain (PBD). How the functional domains of PLKs work together to promote cell division i...

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Autors principals: Ratsima, Hery, Ladouceur, Anne-Marie, Pascariu, Mirela, Sauvé, Véronique, Salloum, Zeina, Maddox, Paul S., D'Amours, Damien
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203808/
https://ncbi.nlm.nih.gov/pubmed/21987786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106448108
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