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Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells
Ribosome stalling triggers the ribosome-associated quality control (RQC) pathway, which targets collided ribosomes and leads to subunit dissociation, followed by proteasomal degradation of the nascent peptide. In yeast, RQC is triggered by Hel2-dependent ubiquitination of uS10, followed by subunit d...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7042231/ https://ncbi.nlm.nih.gov/pubmed/32099016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60241-w |
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