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Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells

Ribosome stalling triggers the ribosome-associated quality control (RQC) pathway, which targets collided ribosomes and leads to subunit dissociation, followed by proteasomal degradation of the nascent peptide. In yeast, RQC is triggered by Hel2-dependent ubiquitination of uS10, followed by subunit d...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Hashimoto, Satoshi, Sugiyama, Takato, Yamazaki, Reina, Nobuta, Risa, Inada, Toshifumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042231/
https://ncbi.nlm.nih.gov/pubmed/32099016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60241-w
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