A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

The conserved transcriptional regulator Heat Shock Factor 1 (Hsf1) is a key sensor of proteotoxic and other stress in the eukaryotic cytosol, yet its regulation is poorly understood. We surveyed Hsf1 activity in a genome-wide loss-of-function library in Saccaromyces cerevisiae as well as ~78,000 dou...

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Bibliografski detalji
Glavni autori: Brandman, Onn, Stewart-Ornstein, Jacob, Wong, Daisy, Larson, Adam, Williams, Christopher C., Li, Gene-Wei, Zhou, Sharleen, King, David, Shen, Peter S., Weibezahn, Jimena, Dunn, Joshua G., Rouskin, Silvi, Inada, Toshifumi, Frost, Adam, Weissman, Jonathan S.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534965/
https://ncbi.nlm.nih.gov/pubmed/23178123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.10.044
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