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Detection and Degradation of Stalled Nascent Chains via Ribosome-Associated Quality Control
Stalled protein synthesis produces defective nascent chains that can harm cells. In response, cells degrade these nascent chains via a process called ribosome-associated quality control (RQC). Here, we review the irregularities in the translation process that cause ribosomes to stall as well as how...
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| Pubblicato in: | Annu Rev Biochem |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8258965/ https://ncbi.nlm.nih.gov/pubmed/32569528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-biochem-013118-110729 |
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