The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation

Ribosome stalling during translation can potentially be harmful, and is surveyed by a conserved quality control pathway that targets the associated mRNA and nascent polypeptide chain (NC). In this pathway, the ribosome-associated quality control (RQC) complex promotes the ubiquitylation and degradat...

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Udgivet i:eLife
Main Authors: Yonashiro, Ryo, Tahara, Erich B, Bengtson, Mario H, Khokhrina, Maria, Lorenz, Holger, Chen, Kai-Chun, Kigoshi-Tansho, Yu, Savas, Jeffrey N, Yates, John R, Kay, Steve A, Craig, Elizabeth A, Mogk, Axel, Bukau, Bernd, Joazeiro, Claudio AP
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Biochemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4805532/
https://ncbi.nlm.nih.gov/pubmed/26943317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.11794
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