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The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon
Cytosolic ribosomes that stall during translation are split into subunits, and nascent polypeptides trapped in the 60S subunit are ubiquitinated by the ribosome quality control (RQC) pathway. Whether the RQC pathway can also target stalls during cotranslational translocation into the ER is not known...
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| Udgivet i: | Mol Biol Cell |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Cell Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4462936/ https://ncbi.nlm.nih.gov/pubmed/25877867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-01-0040 |
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