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Ubiquitination of stalled ribosome triggers ribosome-associated quality control
Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribosome-mediated quality control (RQC) system. Here we report that ubiquitination of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC. We identi...
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| Published in: | Nat Commun |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Nature Publishing Group UK
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5534433/ https://ncbi.nlm.nih.gov/pubmed/28757607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00188-1 |
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