Ubiquitination of stalled ribosome triggers ribosome-associated quality control

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product is degraded by the ribosome-mediated quality control (RQC) system. Here we report that ubiquitination of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC. We identi...

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Published in:Nat Commun
Main Authors: Matsuo, Yoshitaka, Ikeuchi, Ken, Saeki, Yasushi, Iwasaki, Shintaro, Schmidt, Christian, Udagawa, Tsuyoshi, Sato, Fumiya, Tsuchiya, Hikaru, Becker, Thomas, Tanaka, Keiji, Ingolia, Nicholas T., Beckmann, Roland, Inada, Toshifumi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534433/
https://ncbi.nlm.nih.gov/pubmed/28757607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00188-1
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