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Atropselective Disposition of 2,2’,3,4’,6-Pentachlorobiphenyl (PCB 91) and Identification of Its Metabolites in Mice with Liver-specific Deletion of Cytochrome P450 Reductase

Hepatic cytochrome P450 enzymes metabolize chiral polychlorinated biphenyls (PCBs) to hydroxylated metabolites (OH-PCBs). Animal models with impaired metabolism of PCBs are one approach to study how the atropselective oxidation of PCBs to OH-PCBs contributes to toxic outcomes, such as neurodevelopme...

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Publicat a:Chem Res Toxicol
Autors principals: Wu, Xianai, Zhai, Guangshu, Schnoor, Jerald L., Lehmler, Hans-Joachim
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7042073/
https://ncbi.nlm.nih.gov/pubmed/31403789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00255
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