Simultaneous Quantitative LC-MS Method of Ketamine, Midazolam and their Metabolites (Dehydronorketamine, Norketamine and 1Hydroxymidazolam) for its Application in Patients on Extracorporeal Membrane Oxygenation (ECMO) Therapy

Ketamine (Ket) and midazolam (MDZ) are commonly administered drugs in the intensive care setting for analgesia and sedation. Ket and MDZ are metabolized to dehydro-norketamine (DHNK), nor-ketamine (NK) and 1-hydroxy midazolam (1HMDZ). Limited studies evaluating their pharmacokinetics exists in patie...

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Detalhes bibliográficos
Publicado no:J Pharm Biomed Anal
Main Authors: Rochani, Ankit, Lam, Edwin, Tanjuakio, Julian, Hirose, Hitoshi, Kraft, Walter K., Kaushal, Gagan
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041885/
https://ncbi.nlm.nih.gov/pubmed/31708269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.112947
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