Simultaneous Quantitative LC-MS Method of Ketamine, Midazolam and their Metabolites (Dehydronorketamine, Norketamine and 1Hydroxymidazolam) for its Application in Patients on Extracorporeal Membrane Oxygenation (ECMO) Therapy

Ketamine (Ket) and midazolam (MDZ) are commonly administered drugs in the intensive care setting for analgesia and sedation. Ket and MDZ are metabolized to dehydro-norketamine (DHNK), nor-ketamine (NK) and 1-hydroxy midazolam (1HMDZ). Limited studies evaluating their pharmacokinetics exists in patie...

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Veröffentlicht in:J Pharm Biomed Anal
Hauptverfasser: Rochani, Ankit, Lam, Edwin, Tanjuakio, Julian, Hirose, Hitoshi, Kraft, Walter K., Kaushal, Gagan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041885/
https://ncbi.nlm.nih.gov/pubmed/31708269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.112947
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