Simultaneous Quantitative LC-MS Method of Ketamine, Midazolam and their Metabolites (Dehydronorketamine, Norketamine and 1Hydroxymidazolam) for its Application in Patients on Extracorporeal Membrane Oxygenation (ECMO) Therapy

Ketamine (Ket) and midazolam (MDZ) are commonly administered drugs in the intensive care setting for analgesia and sedation. Ket and MDZ are metabolized to dehydro-norketamine (DHNK), nor-ketamine (NK) and 1-hydroxy midazolam (1HMDZ). Limited studies evaluating their pharmacokinetics exists in patie...

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Vydáno v:J Pharm Biomed Anal
Hlavní autoři: Rochani, Ankit, Lam, Edwin, Tanjuakio, Julian, Hirose, Hitoshi, Kraft, Walter K., Kaushal, Gagan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7041885/
https://ncbi.nlm.nih.gov/pubmed/31708269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2019.112947
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